Which of the following is a prokinetic agent used to enhance GI motility?

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Multiple Choice

Which of the following is a prokinetic agent used to enhance GI motility?

Explanation:
Prokinetic drugs speed up the movement of contents through the GI tract by boosting gut contractions. Metoclopramide is a prokinetic because it increases motility in the upper GI tract and speeds gastric emptying. It works by blocking dopamine D2 receptors in the gut (and in the brain’s CTZ) and by stimulating 5-HT4 receptors to increase acetylcholine release, which enhances peristalsis. It can also help with nausea due to its central antiemetic effects. The other drugs don’t enhance motility: ondansetron blocks 5-HT3 receptors to prevent nausea, ranitidine is an H2 blocker that reduces acid, and omeprazole inhibits proton pumps to lower acid production.

Prokinetic drugs speed up the movement of contents through the GI tract by boosting gut contractions. Metoclopramide is a prokinetic because it increases motility in the upper GI tract and speeds gastric emptying. It works by blocking dopamine D2 receptors in the gut (and in the brain’s CTZ) and by stimulating 5-HT4 receptors to increase acetylcholine release, which enhances peristalsis. It can also help with nausea due to its central antiemetic effects. The other drugs don’t enhance motility: ondansetron blocks 5-HT3 receptors to prevent nausea, ranitidine is an H2 blocker that reduces acid, and omeprazole inhibits proton pumps to lower acid production.

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