Which antidote is used to reverse heparin?

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Multiple Choice

Which antidote is used to reverse heparin?

Explanation:
Protamine sulfate reverses heparin by binding to heparin and forming a stable, inactive complex, which quickly neutralizes heparin’s anticoagulant effect. Heparin works by enhancing antithrombin III, so when rapid reversal is needed—such as in excessive bleeding or before emergent surgery—protamine provides a direct, rapid counteraction. Other agents target different drugs: vitamin K reverses warfarin by restoring vitamin K–dependent clotting factors, flumazenil reverses benzodiazepines, and naloxone reverses opioids.

Protamine sulfate reverses heparin by binding to heparin and forming a stable, inactive complex, which quickly neutralizes heparin’s anticoagulant effect. Heparin works by enhancing antithrombin III, so when rapid reversal is needed—such as in excessive bleeding or before emergent surgery—protamine provides a direct, rapid counteraction.

Other agents target different drugs: vitamin K reverses warfarin by restoring vitamin K–dependent clotting factors, flumazenil reverses benzodiazepines, and naloxone reverses opioids.

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