What is true about tetracycline use during pregnancy?

• A. It is contraindicated in pregnancy
• B. It is safe in pregnancy
• C. It should be taken with dairy
• D. It has no effect on fetal development

Answer: (A)

Tetracyclines should not be used during pregnancy because they cross the placenta and can become incorporated into developing fetal bones and teeth. They bind calcium, leading to deposition in calcifying tissues and causing permanent tooth discoloration and enamel defects, and they may interfere with normal bone growth. Because of these risks, tetracyclines are contraindicated in pregnancy.

Taking them with dairy might reduce how much is absorbed, but that does not remove the danger to the fetus, so it does not make the drug safe to use during pregnancy. The idea that tetracyclines are safe in pregnancy or have no effect on fetal development is incorrect.