What is the route of administration for epoetin alfa?

• A. Oral
• B. Intramuscular
• C. Topical
• D. SubQ or IV

Answer: (D)

Epoetin alfa is a protein-based drug, so it must be given by injection to reach the bloodstream intact. If taken by mouth, digestive enzymes would break it down and it wouldn’t work. The standard routes are subcutaneous (under the skin) or intravenous (into a vein), which allow the drug to be absorbed properly and provide the desired effect. Topical or oral routes aren’t effective for this medication, and intramuscular isn’t the typical choice due to absorption variability. So the best answer is subcutaneous or intravenous.